A literature review of clinical and epidemiological studies addressing the risk of cancer in endometriosis

TABLE III: Relationship between endometriosis and non-ovarian gynaecological cancers
Studies	Study design	Entity of the association
		OR, SIR or RR	95% CI
Breast cancer Moseson et al., 1993 Schairer et al., 1997 (A) Schairer et al., 1997 (B) Brinton et al., 1997 Weiss et al., 1999 Venn et al., 1999 Olson et al., 2002 Borgfeldt and Andolf, 2004 Brinton et al., 2005 Cervical cancer Brinton et al., 1997* Berglund et al., 2003* Borgfeldt and Andolf, 2004 Endometrial cancer Brinton et al., 1997 Olson et al., 2002 Borgfeldt and Andolf, 2004 Brinton et al., 2005 Melanoma Wyshak et al., 1989 Frish and Wyshak, 1992 Holly et al., 1995 Brinton et al., 1997 Olson et al., 2002 Brinton et al., 2005 Non-Hodgkin’s lymphoma Brinton et al., 1997* Olson et al., 2002 Berglund et al., 2003*	Case-control Cohort Cohort Cohort Case-control Cohort Cohort Case-control Cohort Cohort Cohort Case-control Cohort Cohort Case-control Cohort Case-control Case-control Case-control Cohort Cohort Cohort Cohort Cohort Cohort	4.3 3.2 3.0 1.3 1.1 1.0 1.0 1.1 0.8 0.7 0.6 0.6 1.1 1.2 0.6 0.8 3.9 1.1 0.9 1.0 0.7 2.1 1.8 1.7 1.2	0.9-20.4 1.2-8.0 0.7-4.1 1.1-1.4 0.7-1.8 0.7-1.5 0.8-1.2 1.0-1.2 0.6-1.1 0.4-1.3 0.5-0.8 0.4-0.9 0.6-1.9 0.6-2.5 0.4-0.8 0.3-1.9 1.2-12.4 0.5-2.3 0.5-1.4 0.7-1.5 0.2-1.8 1.0-4.4 1.2-2.6 1.0-2.9 1.0-1.5

OR: Odds Ratio, SIR: Standardized Incidence Ratio, RR; Relative Risk.
CI: Confidence Interval.

The study from Scharer et al focused on two different cohorts: patients who underwent hysterectomy (A) and those who underwent oophorectomy (B).
[*] The study from Berglund et al (2003) is an extension of the study from Brinton et al (1997).

Reprinted with permission from Elsevier, from:
Somigliana E, Vigano' P, Parazzini F, Stoppelli S, Giambattista E, Vercellini.
Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical
and epidemiological evidence. Gynecol Oncol 2006.

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