A literature review of clinical and epidemiological studies addressing the risk of cancer in endometriosis

TABLE II: Relationship between endometriosis and ovarian cancer
Studies	Study design	Entity of the association
		OR, SIR or RR	95% CI
Brinton et al., 1997* Ness et al., 2000 Ness et al., 2002 Brinton et al., 2004 Borgfeldt and Andolf, 2004 Modugno et al., 2004 Brinton et al., 2005 Melin et al., 2006	Cohort Case-control Case-control Cohort Case-control Case-control Cohort Cohort	1.9 1.7 1.7 1.3 1.3 1.3 1.7 1.4	1.3-2.8 1.2-2.4 1.1-2.7 0.6-2.6 1.0-1.7 1.1-1.6 1.3-2.1 1.2-1.7

OR: Odds Ratio, SIR: Standardized Incidence Ratio, RR; Relative Risk.
CI: Confidence Interval.
[*] The study from Melin et al (2006) is an extension of the study from Brinton et al (1997).

Modified with permission from Elsevier, from:
Somigliana E, Vigano' P, Parazzini F, Stoppelli S, Giambattista E, Vercellini.
Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical
and epidemiological evidence. Gynecol Oncol 2006.

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