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A literature review of clinical and epidemiological studies addressing the risk of cancer in endometriosis


TABLE I: Studies on the frequency of endometriosis in patients with ovarian cancers according to the malignant histotype

Authors
Ovarian cancer histotype
Total
Serous
Mucinous
Endometrioid
Clear cell
Other
Aure et al., 1971
Kurman et al, 1972
Russel, 1979
Vercellini et al., 1993
De La Cuesta et al., 1996*
Toki et al., 1996
Jimbo et al., 1997
Fukunaga et al, 1997
Ogawa et al., 2000
Vercellini et al., 2000
Oral et al., 2003
0% (0/357)
6% (7/118)
3% (7/233)
4% (8/220)
0% (0/10)
10% (9/88)
9% (8/92)
10% (6/63)
7% (4/60)
3% (2/61)
4% (3/70)
1% (1/203)
4% (2/47)
4% (3/69)
6% (6/94)
6% (1/18)
9% (3/33)
3% (1/35)
6% (2/35)
0% (0/17)
3% (1/30)
6% (2/35)
9% (20/212)
11% (4/37)
28% (20/72)
26% (30/114)
39% (9/23)
30% (16/54)
23% (3/13)
42% (13/31)
43% (3/7)
20% (13/66)
22% (4/18)
24% (14/59)
8% (2/28)
48% (16/33)
21% (8/38)
41% (7/17)
50% (22/44)
41% (13/32)
54% (27/50)
70% (30/43)
14% (5/35)
9% (1/11)



12% (11/88)
45% (5/11)
0% (0/16)

67% (2/3)

6% (1/17)
8% (4/49)
4% (35/831)
7% (15/230)
11% (46/407)
11% (63/556)
28% (22/79)
21% (50/235)
15% (25/172)
27% (50/182)
29% (37/127)
10% (22/209)
8% (14/183)

Those studies evaluating association with at least endometrioid, clear cell and seromucinous histotypes have been included.
[*] Only Stage I cancers were included.

Reprinted with permission from Elsevier, from:
Somigliana E, Vigano' P, Parazzini F, Stoppelli S, Giambattista E, Vercellini.
Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical
and epidemiological evidence. Gynecol Oncol 2006.

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