Deficient
intake of antioxidant molecules is related to peripheral
and peritoneal oxidative stress in endometriosis
Researchers in Mexico have evaluated the antioxidant
intake and the lipoperoxidation status in plasma and
peritoneal fluid of women with endometriosis.
They demonstrated that there was an inverse correlation
with the pathology intensity depending on the antioxidant
intake in women with endometriosis. As endometriosis
severity intensifies there is less of an intake of antioxidants.
They also demonstrated a positive association between
the pathology development and the lipoperoxidation status.
The study was carried out in 48 women with endometriosis
obtained at the Sterility Clinic from the National Institute
of Perinatology. The antioxidant intake was evaluated
by applying the Questionnaire Assessment of Antioxidants
and Retinol Intakes in Mexican women validated by the
National Institute of Public Health. The lipoperoxidation
status was determined in plasma and peritoneal fluid
with the malondyaldehyde method. Results were analysed
by ANOVA of Kruskal-Wallis.
The researchers showed that antioxidant intake (vitamin
C, vitamin E, selenium and zinc) in the women with endometriosis
showed a significative statistical difference when compared
with the control group, including the total group and
those stratified in pathology stages. The lipoperoxidation
status in plasma and peritoneal fluid of women with
endometriosis did not show statistical difference versus
healthy women. When data was stratified according to
the severity of pathology, the percentage of lipoperoxidation
status increased in plasma in the severe grade of endometriosis
and in peritoneal fluid in the moderate and severe grades.
|
