Proliferative
activity of early ovarian clear cell adenocarcinoma
depends on association with endometriosis
Researchers in Japan have concluded that the proliferative
activity of early ovarian clear cell adenocarcinoma
seems to depend on the association of this cancer with
endometriosis. When endometriosis is associated with
ovarian clear cell adenocarcinoma, there is a change
of its cytokine production that may inhibit tumour growth.
Komiyama and colleagues divided patients with Stage
I ovarian clear cell adenocarcinoma into groups with
and without endometriosis. Immunohistochemical expression
of proliferating cell nuclear antigen was determined
in surgical specimens. Then, xenograft models of human
ovarian clear cell adenocarcinoma with or without human
ectopic endometrium were created in severe combined
immunodeficiency mice, and tumor growth was assessed
from the wet weight and bromodeoxyuridine uptake. Furthermore,
a xenograft model of human endometriosis was made with
or without ovarian clear cell adenocarcinoma and cytokine
production was investigated.
They showed that the proliferating cell nuclear antigen
labeling index was significantly lower in the tumors
of patients with endometriosis compared to the tumors
of patients without endometriosis.
In tumor-bearing mice, the tumor weight and bromodeoxyuridine
uptake were both significantly lower when ovarian clear
cell adenocarcinoma was associated with endometriosis
than in its absence. Release of transforming growth
factor-beta1 and interleukin-6 from the ectopic human
endometrium was greater in the presence of clear cell
adenocarcinoma than without it, and transforming growth
factor-beta1 levels showed a significant difference.
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