HLA
I expression raised in endometriosis
Researchers in Barcelona suggest that expression of
class I human leukocyte antigen (HLA I) is significantly
higher in endometrial samples from patients with endometriosis
than in those from other people.
In a cross sectional study, 32 patients who underwent
an operation were diagnosed as having only endometriosis
were enrolled, alongside a control group of 20 women
who underwent laparoscopy and were found to have no
evidence of endometriosis or any other genital disease.
Samples of endometrium were obtained by curettage and
immediately frozen. A pan-HLA I mouse antihuman IgG2a
monoclonal antibody was used for immunohistochemical
study.
María Del Mar Vernet-Tomás, who lead the
team of researchres, found that there was significantly
higher expression of HLA I in endometriosis patients
than in controls, at 100%and 80%respectively. In stromal
cells, the same pattern was observed, at a median of
60%and 20%, respectively.
Patients with endometriosis had a significantly higher
expression of HLA I molecules in endometrial cells than
did the controls. This could be a possible explanation
for their higher resistance to natural killer cytolysis.
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